Current position:
2021 PhD student at the Department of Chemistry & Molecular Biology, University of Gothenburg, Sweden
Previous work/positions:
Biologist at Linköping University Hospital
Researcher and Project Leader at LiU iGEM
Education:
BSc (2019) and MSc (2021) in Medical Science with a major in Medical Biology at Linköping University, Sweden.
Research
My research aims to elucidate the many aspects of stress granules (SGs). SGs are cytoplasmic aggregates of proteins and RNAs and act as as a cellular response to stress. The molecular mechanism of SGs during neuronal differentiation has been largely unexplored and I am therefore working on understanding how SGs are processed during neuronal differentiation by studying the turnover of proteins in SGs, their change in composition, and organization. To be able to answer these questions, To answer these above questions, I use correlative imaging of STED, TEM, NanoSIMS, and TOF-SIMS.
SGs have also been connected to many different diseases such as ALS. I am therefore also studying how the SG processing differs between healthy and ALS in different differentiation stages of neuronal cells, from stem cells to mature neurons.
Using correlative imaging techniques I further study the lipid turnover in mamalian oligodendrocytes affected by Schinzel-Giedion Syndrome (SGS). SGSs is a congenital disease in which the affected individuals rarely survive their first decade. Oligodendrocytes have an impaired myelin production in SGS which causes severely disturbed neuronal function such as neurotransmission in SGS children. Potential drug candidates are also studied to observe how myelin production can be restored therapeutically.
Awards:
2020
Inspirer of the year – Awarded by the section for experimental biomedicine, Linköping University.
2019
Best Therapeutics Project, Best Presentation, Best Wiki. Nominated for Best Model, Best Integrated Human Practices, Best New Basic Part, Best New Composite Part, Best Part Collection. (iGEM, Research group award)
Stipends:
2022: Adlerbertska Stipendiet
2021: Adlerbertska Stipendiet
Publications:
Nonionic surfactants can modify the thermal stability of globular and membrane proteins interfering with the thermal proteome profiling principles to identify protein targets
Berlin E, Lizano-Fallas V, Amor AC del, Fresnedo O, Cristobal S. Anal Chem. 2023.
Rabasco S, Lork AA, Berlin E, Nguyen TDK, Ernst C, Locker N, et al. Characterization of Stress Granule Protein Turnover in Neuronal Progenitor Cells Using Correlative STED and NanoSIMS Imaging. Int J Mol Sci. 2023.
Non-peer reviewed publications:
Investigating the function of GroES with hard-to-fold proteins in vivo. (DIVA)